Syrian envoy to Iraq defects: diplomat

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Source: http://news.yahoo.com/syrian-envoy-iraq-defects-diplomat-191053278.html

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INDIA: Lakme Fashion Week Winter/Festive 2012 announces 7 new faces

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Additionally, a 500 Internal Server Error error was encountered while trying to use an ErrorDocument to handle the request.

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Apache Server at www.bharattextile.com Port 80

Source: http://feedproxy.google.com/~r/Bharattextile/~3/IDZdUUSIlUI/2013059

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Parrot Minikit Neo helps you focus on driving, making off-handed Matrix references

Like talking on the phone while driving, but hate all of the crashing it sometimes entails? Parrot's bringing its Minikit Neo to the states later this year, bringing a free Android / iPhone app along for the ride that helps you locate your car, set parking meter fill-up reminders, schedule driving breaks and set auto-replies like, "I'm driving and will call you later," for those times when you're driving and will call people later. The sun-visor-clipping car accessory can connect two Bluetooth-enabled devices simultaneously and features a vibration sensor that'll turn it on and off as you enter and exit the vehicle. The Neo will arrive stateside in September for $100.

Continue reading Parrot Minikit Neo helps you focus on driving, making off-handed Matrix references

Filed under: Cellphones

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Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/2yT9NYQAPZw/

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Study reveals new mechanism that might promote cancer's growth and spread in the body

Public release date: 10-Jul-2012
[ | E-mail | Share ]

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

• Researchers have discovered a previously unknown mechanism that promotes the growth and spread of cancer.
• The mechanism involves a new role for small regulatory molecules called microRNA.
• The findings suggest a new strategy for treating cancer and perhaps diseases of the immune system.

COLUMBUS, Ohio Tiny vesicles released by tumors cells are taken up by healthy immune cells, causing the immune cells to discharge chemicals that foster cancer-cell growth and spread, according to a study by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) and at Children's Hospital in Los Angeles.

The study uses lung cancer cells to show that the vesicles contain potent regulatory molecules called microRNA, and that the uptake of these molecules by immune cells alters their behavior. The process in humans involves a fundamental receptor of the immune system called Toll-like receptor 8 (TLR8).

The findings, published in the early edition of the Proceedings of the National Academy of Sciences, suggest a new strategy for treating cancer and diseases of the immune system, the researchers say, and a new role for microRNA in the body.

"This study reveals a new function of microRNA, which we show binds to a protein receptor," says principal investigator Dr. Carlo Croce, director of Ohio State's Human Cancer Genetics program and a member of the OSUCCC James Molecular Biology and Cancer Genetics program. "This tells us that some cancer-released microRNAs can bind and activate a receptor in a hormone-like fashion, and this has not been seen before."

MicroRNAs help control the type and amount of proteins that cells make, and they typically do this by binding with the messenger-RNA that encodes a protein.

"In this study we discovered a completely new mechanism used by cancer to grow and spread, therefore we can develop new drugs that fight tumors by entering this newly identified breach in cancer's fortress," says co-corresponding author and first author Dr. Muller Fabbri, assistant professor of Pediatrics and Molecular Biology and Immunology at the Keck School of Medicine of the University of Southern California.

"Equally exciting, we show that this mechanism involves a fundamental receptor of the immune system, TLR8, suggesting that the implications of this discovery may extend to other diseases such as autoimmune and inflammatory diseases," Fabbri says.

Key findings of the study include the following:

• Lung tumor cells secrete microRNA-21 and microRNA-29a in vesicles called exosomes, and these exosomes are taken up by immune cells called macrophages located where tumor tissue abuts normal tissue.
• In human macrophages, microRNA-29a and microRNA-21 bind with TLR8, causing the macrophages to secrete tumor-necrosis-factor alpha and interleukin-6, two cytokines that promote inflammation.
• Increased levels of the two cytokines were associated with an increase in the number of tumors per lung in an animal model, while a drop in those levels led to a drop in the number per lung, suggesting that they also play a role in metastasis.

###

Funding from the NIH/National Cancer Institute (grants CA150297, CA135030, CA124541, and CA148302) and a 2009 Kimmel Foundation Fellowship supported this research.

Other researchers involved in this study were Alessio Paone, Federica Calore, Roberta Galli, Eugenio Gaudio, Ramasamy Santhanam, Francesca Lovat, Paolo Fadda, Charlene Mao, Nicola Zanesi, Melissa Crawford, Gulcin H. Ozer, Dorothee Wernicke, Hansjuerg Alder, Michael A. Caligiuri, Patrick Nana-Sinkam and Danilo Perrotti of Ohio State University; and Gerard J. Nuovo of Phylogeny, Inc.

The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute strives to create a cancer-free world by integrating scientific research with excellence in education and patient-centered care, a strategy that leads to better methods of prevention, detection and treatment. Ohio State is one of only 41 National Cancer Institute (NCI)-designated Comprehensive Cancer Centers and one of only seven centers funded by the NCI to conduct both phase I and phase II clinical trials. The NCI recently rated Ohio State's cancer program as "exceptional," the highest rating given by NCI survey teams. As the cancer program's 210-bed adult patient-care component, The James is a "Top Hospital" as named by the Leapfrog Group and one of the top 20 cancer hospitals in the nation as ranked by U.S.News & World Report.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 10-Jul-2012
[ | E-mail | Share ]

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center

• Researchers have discovered a previously unknown mechanism that promotes the growth and spread of cancer.
• The mechanism involves a new role for small regulatory molecules called microRNA.
• The findings suggest a new strategy for treating cancer and perhaps diseases of the immune system.

COLUMBUS, Ohio Tiny vesicles released by tumors cells are taken up by healthy immune cells, causing the immune cells to discharge chemicals that foster cancer-cell growth and spread, according to a study by researchers at The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC James) and at Children's Hospital in Los Angeles.

The study uses lung cancer cells to show that the vesicles contain potent regulatory molecules called microRNA, and that the uptake of these molecules by immune cells alters their behavior. The process in humans involves a fundamental receptor of the immune system called Toll-like receptor 8 (TLR8).

The findings, published in the early edition of the Proceedings of the National Academy of Sciences, suggest a new strategy for treating cancer and diseases of the immune system, the researchers say, and a new role for microRNA in the body.

"This study reveals a new function of microRNA, which we show binds to a protein receptor," says principal investigator Dr. Carlo Croce, director of Ohio State's Human Cancer Genetics program and a member of the OSUCCC James Molecular Biology and Cancer Genetics program. "This tells us that some cancer-released microRNAs can bind and activate a receptor in a hormone-like fashion, and this has not been seen before."

MicroRNAs help control the type and amount of proteins that cells make, and they typically do this by binding with the messenger-RNA that encodes a protein.

"In this study we discovered a completely new mechanism used by cancer to grow and spread, therefore we can develop new drugs that fight tumors by entering this newly identified breach in cancer's fortress," says co-corresponding author and first author Dr. Muller Fabbri, assistant professor of Pediatrics and Molecular Biology and Immunology at the Keck School of Medicine of the University of Southern California.

"Equally exciting, we show that this mechanism involves a fundamental receptor of the immune system, TLR8, suggesting that the implications of this discovery may extend to other diseases such as autoimmune and inflammatory diseases," Fabbri says.

Key findings of the study include the following:

• Lung tumor cells secrete microRNA-21 and microRNA-29a in vesicles called exosomes, and these exosomes are taken up by immune cells called macrophages located where tumor tissue abuts normal tissue.
• In human macrophages, microRNA-29a and microRNA-21 bind with TLR8, causing the macrophages to secrete tumor-necrosis-factor alpha and interleukin-6, two cytokines that promote inflammation.
• Increased levels of the two cytokines were associated with an increase in the number of tumors per lung in an animal model, while a drop in those levels led to a drop in the number per lung, suggesting that they also play a role in metastasis.

###

Funding from the NIH/National Cancer Institute (grants CA150297, CA135030, CA124541, and CA148302) and a 2009 Kimmel Foundation Fellowship supported this research.

Other researchers involved in this study were Alessio Paone, Federica Calore, Roberta Galli, Eugenio Gaudio, Ramasamy Santhanam, Francesca Lovat, Paolo Fadda, Charlene Mao, Nicola Zanesi, Melissa Crawford, Gulcin H. Ozer, Dorothee Wernicke, Hansjuerg Alder, Michael A. Caligiuri, Patrick Nana-Sinkam and Danilo Perrotti of Ohio State University; and Gerard J. Nuovo of Phylogeny, Inc.

The Ohio State University Comprehensive Cancer Center Arthur G. James Cancer Hospital and Richard J. Solove Research Institute strives to create a cancer-free world by integrating scientific research with excellence in education and patient-centered care, a strategy that leads to better methods of prevention, detection and treatment. Ohio State is one of only 41 National Cancer Institute (NCI)-designated Comprehensive Cancer Centers and one of only seven centers funded by the NCI to conduct both phase I and phase II clinical trials. The NCI recently rated Ohio State's cancer program as "exceptional," the highest rating given by NCI survey teams. As the cancer program's 210-bed adult patient-care component, The James is a "Top Hospital" as named by the Leapfrog Group and one of the top 20 cancer hospitals in the nation as ranked by U.S.News & World Report.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-07/osum-srn071012.php

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Mickey Mouse takes NKorean stage in show for Kim

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Source: http://news.yahoo.com/mickey-mouse-takes-nkorean-stage-show-kim-105048866.html

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Carly Rae Jepsen to Perform on 90210 Season 5 Premiere

Call her, definitely, a 90210 Season 5 guest star.

According to TV Line, Carly Rae Jepsen will perform on the October 8 premiere of this CW drama, but, get this: she will NOT be performing "Call Me Maybe."

Instead, network sources confirm, the 26-year Canadian will sing a track off her new album.

 

Carly Rae Jepsen - "Call Me Maybe" (Live in Calgary)

“We fell in love with her song when we first heard it, and used it in last season’s finale before it was a national sensation,” 90210 producers Patti Carr and Lara Olsen said in a statement. “We think she’s an exciting artist and are thrilled to be able to have her music on the show again, this time in a live performance in our season premiere.”

Jepsen just enjoyed her fourth consecutive week on top the Billboard 100 and has has her debut song covered by... just about everybody. Visit our Call Me Maybe remix section now to see what we mean!

Source: http://www.thehollywoodgossip.com/2012/07/carly-rae-jepsen-to-perform-on-90210-season-5-premiere/

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Sony Sees Retail As Important For Growth In Wake Of Gaikai Acquisition

Sony Sees Retail As Important For Growth In Wake Of Gaikai Acquisition

July 6, 2012 - With all the talk surrounding Sony purchasing cloud-based streaming service Gaikai, many were speculating as to what Sony has planned for the future of gaming on its PS3 and PlayStation Vita devices, the looming PS4 and how it will play a factor in purchasing games at various retailers worldwide. While Sony hasn't revealed its true goal behind purchasing on the online service, it did feel the need to address the public and establish where the company stands.

In a discussion between website MCV and Sony UK's Fergal Gara, he let it be known that Sony is committed to retail and that the UK retail market is undergoing "a bit of a readjustment." Sony feels that for the foreseeable future they will need brick-and-mortar establishment to help leverage the PlayStation brand and drive awareness of several of their upcoming products, including the Wonderbook.

While the company is indeed looking towards the future for the PlayStation brand, and Sony as a whole, somehow someway retailers will have a connection to what Sony does digitally. Keep in mind you can go to GameStop to purchase digital goods, which a redeemable on the PlayStation Network. Anything is possible.

SOURCE: MCV

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Source: http://www.gamingevolution.info/view.php?id=13533

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